Vasodilator-induced Hypovolemia in Living Liver Donors: Central Venous Pressure-guided vs Stroke Volume Variation-guided Technique
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 54
- 试验地点
- 2
- 主要终点
- target value of SVV
研究概览
简要总结
Induced hypovolemia is known to improve surgical field during living donor hepatectomy. This procedure is conventionally guided by monitoring the central venous pressure (CVP). Stroke volume variation (SVV) is a novel method to substitute with CVP to monitor cardiac preload. The investigators try to evaluate the relationship between CVP and SVV during CVP-guided vasodilator induced hypovolemia (validation study). Then, feasibility of vasodilator induced hypovolemia using the SVV calculated from the validation study will be tested (feasibility study).
详细描述
This is a 2-phases study.
first phase validation study : Evaluation of the relationship between CVP and SVV during CVP-guided vasodilator induced hypovolemia
second phase feasibility study
: Comparison of the surgical field grade between validation study group(CVP guided group) and feasibility study group(SVV guided group)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult (20-60 yr)
- •elective living liver donors
排除标准
- •not obtained informed consent
结局指标
主要结局
target value of SVV
时间窗: during living donor hepatectomy
Target value of SVV is calculated from the linear regression equation that was calculated from scatter plot made with CVP and SVV values during CVP-guided vasodilator induced hypovolemia (validation study).
次要结局
- surgical field(during living donor hepatectomy)
- use of inotropics(during living donor hepatectomy)
- estimated blood loss(during living donor hepatectomy)
研究者
Chul-Woo Jung
associate professor
Seoul National University Hospital