TRAUMA HELP: Healing and Analgesia With Propranolol
- Registration Number
- NCT01007084
- Lead Sponsor
- University of North Carolina, Chapel Hill
- Brief Summary
The purpose of this study is to determine whether propranolol can decrease pain symptoms in a common subset of patients admitted to a trauma center after injury.
- Detailed Description
The main purpose of this pilot study is to investigate Propranolol's utility in the trauma population. Specifically, to see if it reduces pain scores post-injury.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- at least one fracture
- ages 18-60 yrs
- pain score >= 4
- speak and read English
Exclusion Criteria
- gunshot, stab wound, or assault
- paraplegia/quadriplegia
- pregnancy
- psychotic, suicidal, or homicidal
- hepatic, kidney failure
- clinically unstable or intubated at time of recruitment
- hyperthyroidism
- propranolol use within the last 6 months
- significant bradycardia
- cancer (except basal cell)
- peripheral vascular disease
- heart block > 1 degree
- breastfeeding
- congestive heart failure
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Propranolol Propranolol - Propranolol Propranolol ER - Sugar pill Sugar pills -
- Primary Outcome Measures
Name Time Method Daily average pain score (0-10 numeric rating pain score recorded daily from patient) after study drug initiation. Study days 1, 3, 5, 7, 10, 13, 17, and 19
- Secondary Outcome Measures
Name Time Method Sleep quality MOS Sleep Scale Anxiety symptoms 7 days, 6 weeks, 3 months, 6 months
Trial Locations
- Locations (1)
University of North Carolina Trauma Center
🇺🇸Chapel Hill, North Carolina, United States