Analysis of human uterine temperature and pH and uterine fluid compositio

Recruiting

Conditions: baarmoederomstandigheden en IVF behandeling
Uterus characteristics

Registration Number: NL-OMON54424

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

Reproductive age (18-43 years old)
Regular menstrual cycle
Normal transvaginal ultrasound
Planned ICSI treatment due to (severe) male factor subfertility or planned
fertility treatment with donor sperm
Written informed consent

Exclusion Criteria

Unexplained subfertility, tubal infertility or premature ovarian failure
The presence of untreated unilateral or bilateral hydrosalpinx
A history of dilatation and curettage
Previous caesarean section with niche formation
Malformation of the urogenital system
Endometriosis
Untreated/unsubstituted endocrine abnormalities (e.g. pituitary, thyroid,
adrenal or pancreas abnormalities).
PCOS

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study outcomes will be the mean (SD) temperature and the mean (SD) pH<br /><br>measured in the uterine cavity of women from a Dutch population at the time of<br /><br>the menstrual cycle an embryo normally implants, and the average concentration<br /><br>(mean ± SEM) of at least thirty-seven components present in fluid aspirated<br /><br>from the uteri of the same women at the same time.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The difference between the primary results and previous results from the uteri<br /><br>of Iranian women and the difference between the primary results and the current<br /><br>human embryo culture conditions for human IVF, determined with an independent<br /><br>T-test (temperature and pH) or one-way ANOVA (uterine fluid components).</p><br>