Outcomes of sevoflurane and propofol on left ventricular diastolic function in patients undergoing coronary artery bypass graft surgery.
Not Applicable
- Conditions
- Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery
- Registration Number
- CTRI/2024/04/065898
- Lead Sponsor
- ARMY HOSPITAL REASERCH AND REFERAL NEW DELHI India
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Adult patients undergoing elective coronary artery bypass graft surgery using cardiopulmonary bypass
Exclusion Criteria
LEFT VENTRICULAR EJECTION FRACTION LESS THAN 30%
CARDIOMYOPATHY
PRE EXISTING VALVULAR HEART DISEASE
GRADE 4 DIASTOLIC DYSFUNCTION
ATRIAL FIBRILLATION
SIGNIFICANT PULMONARY DISEASES (EG.ILD,PTE..)
EMERGENCY PROCEDURE
OESOPHAGEAL PATHOLOGY
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate left ventricular diastolic function by measuring Peak flow velocity of early diastolic filling E Early diastolic mitral annulus velocity e using Transesophageal echocardiography(TEE) under sevoflurane or propofol based anaesthesia in patients undergoing Coronary artery bypass graft on cardiopulmonary bypass <br/ ><br>Timepoint: 48hrs
- Secondary Outcome Measures
Name Time Method To compare other parameters of diastolic function between sevoflurane and propofol group ; <br/ ><br> Late diastolic filling(A), <br/ ><br> Deceleration time (DT) , <br/ ><br> Peak systolic flow velocity (S), <br/ ><br> Peak diastolic flow velocity (D), <br/ ><br> S/D ratio, <br/ ><br> Peak reversal atrial flow (Ar), <br/ ><br> Duration of reverse atrial flow (Ar dur), <br/ ><br> Late diastolic mitral annulus velocity(a’). <br/ ><br> <br/ ><br>To determine the Vasoactive inotropic Score (VIS ) between sevoflurane group and propofol group . <br/ ><br> <br/ ><br>To assess the duration of Mechanical ventilation & ICU stay between sevoflurane group and propofol group <br/ ><br>Timepoint: 7 days