Oral Health in Covid-19 Survivors

• Conditions: COVID-19; Periodontitis

• Registration Number: NCT05205694
• Lead Sponsor: University of Belgrade

Brief Summary

Aims are to assess periodontal health and salivary stress/ immunity responses in COVID-19 survivors

Detailed Description

There are lack of data concerning oral health in COVID-19 survivors, nevertheless, many middle-aged patients with oral symptoms of Post-acute COVID-19 report xerostomia and taste impairment and suffer from oral hypofunction, thus may be susceptible to periodontitis and oral frailty. Post-acute or long COVID-19 is/would be the health hallmark of post-COVID-19 era, manifested as a multiplicity of clinical problems and requiring conceptual framework aiming at multidisciplinary health preserving activities. There are various factors which may affect oral and periodontal health in post-COVID-19 era, such as disruption of dental professional care due to the fear of infection, virus-induced disturbance of oral homeostasis and, as a common denominator- COVID-19-induced psychological stress. Expected results would not just offer epidemiological data but also, mechanistic background for defining risks and modified measures aiming to preserve oral health in post-COVID-19 era.

Study Timeline

• Status Verified: 2021-09
• Study Start: 2021-09-20
• Study First Submitted: 2022-01-22
• Study First Submitted QC: 2022-01-22
• Last Update Submitted: 2022-01-22
• Study First Posted: 2022-01-25
• Last Update Posted: 2022-01-25
• Primary Completion: 2022-05-31
• Study Completion: 2023-06-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 210

Inclusion Criteria

• self-reported good general health, ≥ 14 erupted teeth excluding third molars. For periodontally healthy: Bleeding on probing score ≤10%, without attachment loss and radiographic bone loss and probing depth ≤ 3 mm in every site (Trombelli L et al., 2018). For periodontitis patients: periodontitis in stages II-IV.

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Exclusion Criteria

• history of periodontal treatment in previous six months, acute oral infection, presence of systemic disease(s), pregnancy, lactation, smoking ≥ 10 cigarettes per day

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Periodontal disease stage and COVID 19	one to six months after COVID-19	Correlation periodontitis and COVID 19 infection

Secondary Outcome Measures

Name	Time	Method
psychological stress	one to six months after COVID-19	Assessment of psychological stress
salivary stress/immunity mediators	one to six months after COVID-19	Association of salivary stress/immunity mediators levels with perio disease in COVID 19 patients
Oral frailty	one to six months after COVID-19	Oral frailty assessment in Covid 19 and Perio affected patients

Trial Locations

Locations (1)

School of Dental Medicine University of Belgrade; 🇷🇸 Belgrade, Serbia