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临床试验/NCT05205694
NCT05205694Unknown不适用

Biomarkers of Oral Health in Covid-19 Survivors

University of Belgrade1 个研究点 分布在 1 个国家目标入组 210 人开始时间: 2021年9月20日最近更新:
适应症

试验速览

阶段
不适用
入组人数
210
试验地点
1
主要终点
Periodontal disease stage and COVID 19

研究概览

简要总结

Aims are to assess periodontal health and salivary stress/ immunity responses in COVID-19 survivors

详细描述

There are lack of data concerning oral health in COVID-19 survivors, nevertheless, many middle-aged patients with oral symptoms of Post-acute COVID-19 report xerostomia and taste impairment and suffer from oral hypofunction, thus may be susceptible to periodontitis and oral frailty. Post-acute or long COVID-19 is/would be the health hallmark of post-COVID-19 era, manifested as a multiplicity of clinical problems and requiring conceptual framework aiming at multidisciplinary health preserving activities. There are various factors which may affect oral and periodontal health in post-COVID-19 era, such as disruption of dental professional care due to the fear of infection, virus-induced disturbance of oral homeostasis and, as a common denominator- COVID-19-induced psychological stress. Expected results would not just offer epidemiological data but also, mechanistic background for defining risks and modified measures aiming to preserve oral health in post-COVID-19 era.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • self-reported good general health, ≥ 14 erupted teeth excluding third molars. For periodontally healthy: Bleeding on probing score ≤10%, without attachment loss and radiographic bone loss and probing depth ≤ 3 mm in every site (Trombelli L et al., 2018). For periodontitis patients: periodontitis in stages II-IV.

排除标准

  • history of periodontal treatment in previous six months, acute oral infection, presence of systemic disease(s), pregnancy, lactation, smoking ≥ 10 cigarettes per day

结局指标

主要结局

Periodontal disease stage and COVID 19

时间窗: one to six months after COVID-19

Correlation periodontitis and COVID 19 infection

次要结局

  • psychological stress(one to six months after COVID-19)
  • salivary stress/immunity mediators(one to six months after COVID-19)
  • Oral frailty(one to six months after COVID-19)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Jelena Roganović

Associate Professor

University of Belgrade

研究点 (1)

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