Desflurane Versus Propofol in the Sitting Position

Not Applicable

Completed

• Conditions: Cerebral Ischemia
• Interventions: Drug: Desflurane; Drug: propofol; Drug: alfentanil; Drug: Rocuronium

• Registration Number: NCT01436799
• Lead Sponsor: Gachon University Gil Medical Center

Brief Summary

The investigators hypothesized that both propofol and desflurane would decrease the regional oxygen saturation (rSO2) but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position.

Detailed Description

The investigators hypothesized that both propofol and desflurane would decrease the rSO2 but propofol is likely to reduce rSO2 more than sevoflurane when patients are raised to the sitting position. Therefore, the purpose of this study was to investigate the effect of desflurane and propofol on rSO2 values during the beach chair position for shoulder arthroscopy.

Study Timeline

• Study Start: 2011-03
• Primary Completion: 2011-08
• Study Completion: 2011-08
• Study First Submitted: 2011-09-15
• Study First Submitted QC: 2011-09-19
• Study First Posted: 2011-09-20
• Results First Submitted: 2013-02-05
• Status Verified: 2013-08
• Results First Submitted QC: 2013-08-22
• Last Update Submitted: 2013-08-25
• Results First Posted: 2013-08-26
• Last Update Posted: 2013-09-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Forty patients,
• ASA class I or II,
• undergoing shoulder arthroscopy

Exclusion Criteria

• Patients with history of cerebrovascular disease, coronary occlusive disease and/or obesity (body mass index > 30) were excluded from this study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Desflurane	Desflurane	anaesthesia was induced with thiopental sodium 2 mg kg-1, alfentanil 10 μg kg-1 and rocuronium 0.6 mg kg-1. Anesthetic maintenance by desflurane
Desflurane	alfentanil	anaesthesia was induced with thiopental sodium 2 mg kg-1, alfentanil 10 μg kg-1 and rocuronium 0.6 mg kg-1. Anesthetic maintenance by desflurane
Desflurane	Rocuronium	anaesthesia was induced with thiopental sodium 2 mg kg-1, alfentanil 10 μg kg-1 and rocuronium 0.6 mg kg-1. Anesthetic maintenance by desflurane
propofol	propofol	anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1, alfentanil 10 μg kg-1, and rocuronium 0.6 mg kg-1. A commercially available target controlled infusion (TCI) pump (Orchestra®, Fresenius Vial, France) was used and the pharmacokinetic set used to calculate target effect-site concentrations for propofol was Schnider and colleagues' model
propofol	Rocuronium	anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1, alfentanil 10 μg kg-1, and rocuronium 0.6 mg kg-1. A commercially available target controlled infusion (TCI) pump (Orchestra®, Fresenius Vial, France) was used and the pharmacokinetic set used to calculate target effect-site concentrations for propofol was Schnider and colleagues' model
propofol	alfentanil	anaesthesia was induced with the effect-site concentration of propofol 5.0 μg ml-1, alfentanil 10 μg kg-1, and rocuronium 0.6 mg kg-1. A commercially available target controlled infusion (TCI) pump (Orchestra®, Fresenius Vial, France) was used and the pharmacokinetic set used to calculate target effect-site concentrations for propofol was Schnider and colleagues' model

Primary Outcome Measures

Name	Time	Method
Regional Cerebral Oxygen Satuation (rSO2)	1, 3, 5, 7, and 9 min after the beach chair position	definitive values of regional cerebral oxygen saturation(rSO2,%) values are described as mean (SD)