Comparison of effectiveness of intravenous Dexmedetomidine vs fentanyl for attenuation of hemodynamic response to pneumoperitonium in laparoscopic cholecystectomy at SMS College Jaipur During 2018-19: A randomised double blind interventional study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- To assess and compare the change in hemodynamic variables (HR,SBP,DBP,MAP) after pneumoperitoneum in both the study groups.
研究概览
简要总结
Dexmedetomidine is a highily selective alpha2 agonist that provides anxiolysis,analgesia and cooperative sedation without respiratory depression.Fentanyl is a potent synthetic mu receptor opoid agonist that produces dose dependent analgesia and sedation. In this study we aim to compare the effectiveness of inj.Dexmedetomidine Vs inj.Fentanyl for attenuation of hemodynamic response to pneumoperitonium in laproscopic cholecystectomy.We hypothesize that Dexmedetomine would be better in controlling haemodynamic parameters and pain then in Fentanyl.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients with ASA grade I and II 2.Patients willing to give written informed consent.
- •3.Age Groups 18 to 50 years 4.Weighing 40 to 70 kg.
- •5.Scheduled for elective laparoscopic cholecystectomy.
排除标准
- •1.Patients not willing to participate in study 2.Patients having history of allergy to anaesthestic agents used in study 3.Patients with pre-existing cardiac disease, Hypertension ,Asthama,Renal or Hepatic dysfunction 4.Patients with anticipated difficult intubation i.e Mallampati class 3 or more,restricted neck movement or restricted mouth opening.
结局指标
主要结局
To assess and compare the change in hemodynamic variables (HR,SBP,DBP,MAP) after pneumoperitoneum in both the study groups.
时间窗: Data will be recorded Just Before induction,1min after induction,1 min after intubation,3min after intubation,1min after PNP and 10min interval in PNP throughout the surgery and after extubation
次要结局
- 1. To assess and compare the duration of post operative analgesia in both the study groups.(2. To determine post-operative sedation level in both the study groups.)