COMPARISION OF EFFECTIVENESS OF DEXMEDETOMIDINE(A MULTIPURPOSE DRUG USED IN ANAESTHESIA) VS ESMOLOL(USED FOR CONTROL OF HIGH BP & HEART RATE) IN DECREASING THE HYPERTENSION & TACHYCARDIA OCCURING DURING PASSAGE OF BREATHING TUBE INTO LUNGS IN PATIENTS WITH HIGH BP WHO ARE ON TREATMENT

Not Applicable

Completed

• Conditions: Hypertensive patients on treatment with good control of blood pressure

• Registration Number: CTRI/2013/06/003741

Brief Summary

Hypertension    and     tachycardia     are   frequently   associated   with   direct   laryngoscopy    and   endotracheal   intubation(LETI)   after   induction  of   anaesthesia. Patients  with   hypertension,     both   treated    and     untreated, are  prone to exaggerated   pressor    response    to  LETI  than  are normotensive   patients.The exaggerated  pressor  response to LETI  in  these patients  can  evoke life-threatening   condtions  which include myocardial  ischemia,  pulmonary oedema, cardiac  failure  and cerebral  haemorrhage. Few   studies  have   been   carried out with consideration to attenuate   the   hemodynamic response  to  laryngoscopy  in  the subgroup   of    patients    with   hypertension. Nitroglycerine,  verapamil,diltiazem, esmolol, alfentanil and   remifentanil   have been used of whichesmolol was found to be most effective. Dexmedetomidine, a clonidine-like α2-agonistis a sedative-hypnotic and  analgesic. The mechanism by whichdexmedetomidine produces its actions is mainly through central sympatholysisand decreased circulating levels of catecholamines. Since cardiovascular responseto LETI is sympathetically driven, it can be catastrophic, especially inhypertensives due to their enhanced sensitivity to circulating catecholamines.It is therefore hypothesised that dexmedetomidine can effectively blunt thesympatho-adrenal response to LETI, thereby resulting in decreased morbidity inhypertensive patients. Hence this present study aims to study a new drugdexmedetomidine against the previously established drug esmolol in blunting ofcardiovascular response to LETI.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-02-05
• Last Update Posted: 2013-10-06

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Ninety patients of ASA physical status II & III, of either sex, aged between 35-65 years and undergoing elective surgery requiring general anaesthesia will be included in the study.
• Controlled hypertensive patients with blood pressure less than 160/100 mmHg receiving oral antihypertensive medication for a minimum period of six weeks will be studied.

Exclusion Criteria

•Patients with anticipated difficult intubation •Physical status > ASAIII •Hiatus hernia, gastro-oesophageal reflux disease •Obesity ( BMI > 30 kg/m2) •Those on long-term sedatives, hypnotics, antidepressants, drugs affecting nervous system •Previous myocardial infarction or angina pectoris, congestive heart failure • Heart blocks •Neurosurgical patients •History of allergy to dexmedetomidine or esmolol.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the effectiveness of dexmedetomidine versus esmolol in blunting of the hemodynamic and bispectral index(BIS) response to laryngoscopy and intubation in treated hypertensive patients undergoing elective surgery	It will be a randomized double- blind study conducted between january 1st 2011 to December 31st 2011(one year).

Secondary Outcome Measures

Name	Time	Method
The study also aims at measuring dexmedetomidine’s effect on isoflurane requirements.	It will be a randomized double- blind study conducted between january 1st 2011 to December 31st 2011(one year).

Trial Locations

Locations (1)

NEHRU HOSPITALPGIMER; 🇮🇳 Chandigarh, CHANDIGARH, India

NEHRU HOSPITALPGIMER

🇮🇳Chandigarh, CHANDIGARH, India

KIRAN BHARATH JUNIOR RESIDENT DEPARTMENT OF ANAESTHESIA PGIMER CHANDIGARH

Principal investigator

9914589448

kbharath2003@gmail.com