Comparing two drugs i.e. Nalbuphine and Dexmedetomidine in attenuating intubation response ( increase in blood pressure and heart rate while inserting endotracheal tube) in patients for surgeries under general anaesthesia.
Not Applicable
- Conditions
- Health Condition 1: null- patients undergoing elective surgery under general anaesthesia
- Registration Number
- CTRI/2018/05/013656
- Lead Sponsor
- Principal Dr RPGMC Kangra at Tanda
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Male and female patients undergoing elective surgeries under general anaesthesia.
2.Amercian society of Anesthesiologist physical status I-II.
3.BMI between 18.5-29.9 Kg/m2
Exclusion Criteria
1.Age <20yrs and >60yrs.
2.ASA grade 3 and 4.
3.History of allergy to any of study drugs.
4.Patients with peri-operative heart rate < 55bpm and/or Systolic BP < 90mmHg.
5.Patients receiving other alpha 2 agonists like clonidine or other opioid.
6.Patients noted to have dysrhythmias on the electrocardiogram (ECG).
7.Unwilling patients.
8.Patients who are opioid tolerant or opioid dependent.
9.Pregnant women.
10.Anticipated difficult intubation.
11.Patient with cardiac, pulmonary, neurologic, kidney diseases.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the changes in HR and BP after laryngoscopy and intubation.Timepoint: Haemodynamic response every 1 min till 5 min and there onwards at 10 min,20 min,30 min
- Secondary Outcome Measures
Name Time Method To study and compare PONV and sedation score. <br/ ><br>To observe for side effects of any of study drugs, if any.Timepoint: in interval of 2nd, 4th, 8th, 12th, 18th, 24th hour in post-operative period: <br/ ><br>