Neuroimaging Studies of Depression in Parkinson's Disease
- Conditions
- Parkinson's Disease
- Registration Number
- NCT00518258
- Lead Sponsor
- Lee Blonder
- Brief Summary
The purpose of this study is to investigate similarities and differences in the neural pathways of depressed Parkinson's patients, non-depressed Parkinson's patients, and healthy controls using magnetic resonance imaging (MRI) of the brain and neuropsychological assessment.
- Detailed Description
Depression is a common and potentially serious complication of Parkinson's disease (PD). Studies show that approximately 40 percent of PD patients are depressed. There is evidence that these patients have deficits in neuropsychological function relative to non-depressed PD patients. Despite the widespread toll on emotional health posed by PD, few studies have undertaken a comprehensive examination of the neural underpinnings of Parkinsonian depression. In this project, we will compare depressed versus non-depressed Parkinson patients to a sample of demographically-matched healthy controls using neuropsychological assessment and magnetic resonance imaging (MRI). To investigate possible effects of anti-Parkinsonian medication on mood, cognitive function, and neural response, PD patients will be tested both off and on Parkinsonian medications.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 120
- right-handed
- willing/able to undergo magnetic resonance imaging (MRI)
- history of neurological condition other than Parkinson's disease
- history of psychiatric condition other than depression
- history of substance abuse/dependence
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Kentucky
🇺🇸Lexington, Kentucky, United States
University of Kentucky🇺🇸Lexington, Kentucky, United States