Comparison of Sevoflurane with Propofol based anesthesia technique on echocardiographic strain values in patients undergoing elective aortic valve replacement
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/03/050850
- Lead Sponsor
- Markose L Paret
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
All adults above 18 years of age, in sinus rhythm, admitted with severe aortic stenosis with good LV function (Left ventricular ejection fraction more than or equal to 50%) for elective aortic valve replacement surgery will be included in the study
1.Emergency surgeries
2.Redo surgeries
3.Patients not willing to participate in study
4.More than mild AR, MR or TR
5.Patients with coronary artery disease defined by lumen stenosis more than or equal to 50% in atleast one of major epicardial coronaries on coronary angiogram.
6.Patients receiving preoperative inotropes
7.Patients with poor echo differentiation of endocardial borders
8.Contraindication to TEE probe placement like esophageal strictures, esophageal varices, esophageal tumours, gastric ulcer, previous esophagectomy, esophageal diverticulum, tracheoesophageal fistula, previous bariatric surgery, hiatus hernia, large descending thoracic aortic aneurysm, unilateral vocal cord paralysis, esophageal varices, post-radiation therapy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Change in global longitudinal and global circumferential strain after aortic valve replacement in patients of severe aortic stenosis with good left ventricular ejection fraction <br/ ><br> <br/ ><br>2. Compare effects of sevoflurane and propofol anaesthesia on changes in global longitudinal and circumferential strain after aortic valve replacement in patients of severe aortic stenosis with good left ventricular ejection fraction. <br/ ><br>Timepoint: 1. Strain echocardiography before aortic valve replacement in intraoperative period. <br/ ><br>2. Strain echocardiography after aortic valve replacement in intraoperative period
- Secondary Outcome Measures
Name Time Method 1. Assess preoperative global longitudinal and circumferential strains in patients with severe aortic stenosis and good left ventricular ejection fraction. <br/ ><br>2. To study risk factors associated with preoperative changes in global longitudinal and circumferential strain in patients with severe aortic stenosis and good left ventricular ejection fraction. <br/ ><br>Timepoint: 1.Risk factor evaluation during preoperative anaesthesia check up. <br/ ><br>2. Strain echocardiography before aortic valve replacement in intra operative period. <br/ ><br> <br/ ><br>3.Strain echocardiography after aortic valve replacement in intraoperative period.