Influence of sevoflurane and propofol on maximum muscular strength, speed of contraction and relaxation.
- Conditions
- Impact of anesthetic drugs on neuromuscular transmissionTherapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
- Registration Number
- EUCTR2022-003737-19-BE
- Lead Sponsor
- CHU Brugmann
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 48
-Patients (male or female) from 18 – 80 years
-Scheduled for surgery without the use of neuromuscular blocking agents
-Health care insurance in Belgium
-Written informed consent
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 36
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 12
-Any pathology involving neuromuscular transmission
-Confirmed neuropathy of any origin
-Expected anesthesia duration < 30 min
-Renal insufficiency defined as a glomerular filtration rate < 40 mL/min/m2
-Hepatic insufficiency defined as an increase > 1.5 * normal value of hepatic enzymes
-Confirmed or suspected pregnancy
-Language barrier
-Any patient which will receive unplanned neuromuscular blocking agents during surgery
-Any history of personal or familial suspected malignant hyperthermia
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method