Influence Of Circulating Microvesicles On Vascular Inflammatio

Recruiting

Conditions: I25.1
I70.2
Atherosclerotic heart disease
Atherosclerosis of arteries of extremities

Registration Number: DRKS00009324

Lead Sponsor: Charité Universitätsmedizin BerlinKlinik für KardiologieCampus Benjamin Franklin

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 200

Inclusion Criteria

1. in all groups age between 30 and 75 years
2. in all groups male and female subjects
Age and sex should be homogenously distributed among study arms
Group 1: healthy volunteers (i.e. no known cardiac disease, no family history)
Group 2: patients with stable coronary artery disease
Groups 3: patients with peripheral artery occlusive disease

Exclusion Criteria

1. pregnancy
2. renal failure (creatinin >265 umol)
3. liver failure
4. disease of the hematopoetic system
5. malignancy within the past 5 years (without evidence of relapse at time of inclusion)
6. acute or chronic inflammation
7. acute vascular event (e.g. myocardial infarction, stroke, pulmonary or systemic embolism) within the last year
8. inability to give informed consent
9. solid organ transplantation in history
10. acute shock
11. metabolic diseases including heredetary lipometabolic diseases and diabetes

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Microvesicle secretion profiles of different circulating leukocytes in healthy subjects and patients with coronary artery disease or peripheral artery occlusive disease

Secondary Outcome Measures

Name	Time	Method
Microvesicle function in different leukocyte populations in healthy subjects and patients with coronary artery disease or peripheral artery occlusive disease