A Comparison Between Palonosetron Versus Granisetron as PONV Prophylaxis in Scoliotic Patients Undergoing Spine Surgery
- Conditions
- Postoperative Nausea and VomitingScoliosis
- Registration Number
- NCT06540885
- Lead Sponsor
- University of Malaya
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not yet recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria:<br><br> - Age: 10 years and above<br><br> - American Society of Anesthesiologists (ASA) class I-II<br><br>Exclusion Criteria:<br><br> - Active smoker<br><br> - Obesity with body mass index (BMI) of 34 and above<br><br> - Body weight of less than 30kg<br><br> - History of gastro-esophageal reflux disease (GERD)/ other gastrointestinal diseases<br> associated with vomiting<br><br> - History of motion sickness<br><br> - History of allergy to 5-HT3 (serotonin) receptor antagonists or dexamethasone<br><br> - History of nausea or vomiting withing 24 hours before surgery<br><br> - History of administration of antiemetics/ steroids/ psychoactive medications within<br> 24 hours before the surgery<br><br> - History of cardiac arrhythmias<br><br> - Prolonged QT (QTc is prolonged if > 430ms in men or >450ms in women)
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of postoperative nausea and vomiting (PONV) delayed postoperative nausea and vomiting (PONV) in adult and adolescent idiopathic scoliosis patients;Incidence of postoperative nausea and vomiting (PONV);Incidence of postoperative nausea and vomiting (PONV);Incidence of postoperative nausea and vomiting (PONV);Incidence of postoperative nausea and vomiting (PONV)
- Secondary Outcome Measures
Name Time Method To evaluate the need for rescue antiemetics among participants;To evaluate the adverse effects related to the study drugs.;To assess the degree of participant's satisfaction.