Optimization of exercise therapy in type 2 diabetes mellitus - Hypo- and hyperoxic exercise & glycemic profile in DM2

Erasmus MC, Universitair Medisch Centrum Rotterdam0 个研究点目标入组 56 人开始时间: 待定最近更新: 2024年4月29日

适应症

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•Diabetes patients(n=12):
•Type 2 Diabetes Mellitus >3 months.
•Age: 40-65 years.
•BMI between 27 and 35 kg/m2.
•Formal permission to participate in the study by signing an informed consent form.
•Healthy subjects(n=20):
•Age:18-40 years.
•BMI:23-26 kg/m2
•Formal permission to participate in the study by signing an informed consent form.
•Overweight /Obese subjects - glucosetolerant(n=12):
•Age: 40-65 years;
•BMI >27 kg/m2;
•HbA1c <6.0%;
•Formal permission to participate in the study by signing an informed consent form.
•Overweight /Obese subjects - glucoseintolerant(n=12):
•Age: 40-65 jaar;
•BMI > 27 kg/m2;
•HbA1c >=6.0%;
•Formal permission to participate in the study by signing an informed consent form.

•Cardiovascular disease: objective heart failure (ejection fraction <35%), electrocardiographically diagnosed cardiac ischemia or symptomatic peripheral vascular disease diagnosed by Doppler ultrasound investigation
•Serious orthopedic of neurological conditions precluding an exercise test.
•Healthy subjects:
•Positive signs of cardiac ischaemia on the ECG (ST>2mm) during the incremental exercise test;
•Orthopaedic impairments that would limit participation in the study.
•Obese volunteers - glucose tolerant:
•Positive signs of cardiac ischaemia on the ECG (ST>2mm) during the incremental. exercise test;
•Orthopaedic impairments that would limit participation in the study.
•Use of β-blockers, a-blockers, calcium antagonists.
•Obese volunteers - glucose intolerant:
•Positive signs of cardiac ischaemia on the ECG (ST>2mm) during the incremental. exercise test;
•Orthopaedic impairments that would limit participation in the study.
•Use of β-blockers, a-blockers, calcium antagonists.

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