The effects of protein dose response on myofibrillar and mitochondral protein synthesis after endurance exercise in young me
- Conditions
- Young males, Muscle protein synthesis
- Registration Number
- NL-OMON24647
- Lead Sponsor
- TRIM School for Nutrition, Toxicology, and Metabolism Maastricht University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 64
Inclusion Criteria
Males
-Aged between 18-35 years
Exclusion Criteria
-Having any identified metabolic or intestinal disorders
-Use of tobacco products
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Muscle protein synthesis rate (myofibrillar and mitochondrial)
- Secondary Outcome Measures
Name Time Method •The fractional synthetic rate (FSR) of muscle protein synthesis (myofibrillar, and mitochondrial proteins) from 0-3 and 3-6 hours in the post-prandial period.<br /><br>•Plasma free L-[ring-2H5]-phenylalanine enrichment (expressed as MPE)<br /><br>•Plasma free L-[ring-2H4]-tyrosine enrichment (expressed as MPE)<br /><br>•Plasma free L-[3,5-2H2]-tyrosine enrichment (expressed as MPE)<br /><br>•Plasma free L-[ring-2H5]-phenylalanine enrichment<br /> <br>•Plasma free L-[1-13C]-leucine enrichment <br /><br>•Plasma free L-[1-13C]-KIC enrichment <br /><br>•Plasma total phenylalanine (expressed as ìmol/L)<br /><br>•Plasma total tyrosine (expressed as ìmol/L)<br /><br>•Total plasma amino acids (AAmax [ìmol/L])<br /><br>•Plasma glucose (glucosemax [mmol/L])<br /><br>•Plasma insulin (insulinmax [mU/L])<br>