Contrast-Enhanced US of Spleen, Liver and Kidney

• Conditions: Malaria; Pyelonephritis; Bacterial Infections

• Registration Number: NCT00190281
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

To evaluate the changes in the microcirculation of the liver, kidney and spleen during acute infection in patients with malaria (cohorts 1 and 3) and other infectious diseases such as acute pyelonephritis at day 0 (within 8 hours of the treatment start), day 2 to 4 and day 28-32, using functional US with continuous infusion of a contrast agent (SonoVue, Bracco, Italy).

Study hypothesis: malaria patients should exhibit a different pattern of enhancement, particularly when quantitative measurements of the SU signals is performed with destruction reperfusion kinetics.

Detailed Description

To evaluate the changes in the microcirculation of the liver, kidney and spleen during acute infection in patients with malaria (cohorts 1 and 3) and other infectious diseases such as acute pyelonephritis at day 0 (within 8 hours of the treatment start), day 2 to 4 and day 28-32, using functional US with continuous infusion of a contrast agent (SonoVue, Bracco, Italy).

Three cohortes will be studied: cohorte 1 infection at Plasmodium falciparum (24 patients), cohorte 3 infection at Plasmodium vivax, ovale or malariae (5 patients) and cohorte 2 other infectious diseases such as acute pyelonephritis (24 patients).

Study hypothesis: malaria patients should exhibit a different pattern of enhancement, particularly when quantitative measurements of the SU signals is performed with destruction reperfusion kinetics.

Study Timeline

• Status Verified: 2005-03
• Study Start: 2005-08
• Study First Submitted: 2005-09-13
• Study First Submitted QC: 2005-09-13
• Study First Posted: 2005-09-19
• Last Update Submitted: 2005-12-12
• Last Update Posted: 2005-12-13

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 53

Inclusion Criteria

• Social security number
• Age over 18
• acute malaria infection or other infectious diseases
• Inpatients
• Signed informed consent form

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Exclusion Criteria

• Pregnancy
• Criteria of bad tolerance of infection
• Treatment started for more than 8 hours
• Lack of cooperation
• History of splenectomy, hematological disease, cirrhosis with portal hypertension, splenomegaly
• Medical treatment with beta blocker, diuretic, immunodepression drugs

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Department of Adult Radiology, Necker University Hospital; 🇫🇷 Paris, Ile de france, France