Combined Nutrient Intake and Muscle Protein Synthesis
Not Applicable
Completed
- Conditions
- Aging
- Interventions
- Other: proteinOther: protein and carbohydrateOther: protein and leucine
- Registration Number
- NCT01239277
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether combined nutrient intake plays an important role in stimulation of the muscle protein growth in elderly people; and whether it represent effective strategies to overcome the impaired muscle protein synthesis in elderly when compared with young subjects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 48
Inclusion Criteria
- males
- 70-85 years or 18-30 years
- BMI < 30
Exclusion Criteria
- Type II diabetes
- All co morbidities interacting with mobility and muscle metabolism of the lower limbs
- Use of anticoagulants
- Patients suffering from Phenylketonuria
- Participation in any regular exercise programme
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description protein (elderly) protein - protein and carbohydrate (elderly) protein and carbohydrate - protein and carbohydrate (young) protein and carbohydrate - protein and leucine (elderly) protein and leucine -
- Primary Outcome Measures
Name Time Method Muscle protein synthesis 6 h postprandial period Muscle protein synthesis will be expressed as fractional synthetic rate (FSR) by dividing the increment in enrichment in the product, i.e. protein-bound C13phe, by the enrichment of the precursor (=plasma availability).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Universiteit Maastricht, Bewegingswetenschappen
🇳🇱Maastricht, Limburg, Netherlands