Evaluating the efficacy of methotrexate in pain severity reduction and improvement of quality of life in patients with moderate to severe knee osteoarthritis
Not Applicable
Recruiting
- Conditions
- Knee osthoarthritis.
- Registration Number
- IRCT20170716035126N1
- Lead Sponsor
- Ardabil University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Knee osteoarthritis with effusion; age between 45-75 years; ability to walk; having pain score of >5 according to VAS and >48 according to WOMAC questionnaire
Exclusion Criteria
Other knee disorders; concomitant hip and ankle osteoarthritis; bursitis and perarticular disease; radicular pains; physiotherapy or intraarticular injection during the past 6 months; psychological disease; history of knee surgery; inflammatory joint disease; rheumatoid arthritis; fibromyalgia; active or recurrent pseudogoat; malignancy; systemic diseases including renal of hepatic failure, uncontrolled blood pressure, diabetes mellitus; asthma in need of corticosteroids; corticosteroid use in less than 5 weeks prior to study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain. Timepoint: before intervention and three and six months after intervention. Method of measurement: using visual analogue scale (VAS).
- Secondary Outcome Measures
Name Time Method Functional status. Timepoint: before intervention and three and six months after intervention. Method of measurement: using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire.;Quality of life. Timepoint: before intervention and three and six months after intervention. Method of measurement: using SF-12 quality of life questionnaire.