Effectiveness of oral midodrine drug in reducing vasopressor dependence among ICU patients with septic shock:A prospective Randomized Trial.
Phase 2
- Conditions
- Health Condition 1: R652- Severe sepsis
- Registration Number
- CTRI/2023/11/059796
- Lead Sponsor
- A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Septic shock patients on dual vasopressor support
Exclusion Criteria
CKD
PREGNANCY
PRE-EXISTING LOVER DISEASE
BRADYCARDIA of <50bpm
Severe organic heart disease
Known allergy to midodrine
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time is taken to de-escalate to a single low-dose vasopressor (defined as noradrenaline =0.15 µg/kg/min) after administration of oral midodrine or placebo.Timepoint: During the course of icu stay
- Secondary Outcome Measures
Name Time Method 1.Vasoactive inotropic score (VIS) score trend, recorded 6th hourly till the patient is off inotropic support. <br/ ><br>Timepoint: During the icu stay;2. Maximum VIS score during ICU stay. <br/ ><br>Timepoint: During the icy stay;3. Mean VIS during ICU stay. <br/ ><br>Timepoint: During icu stay;4. Time taken for complete weaning off from inotropic support (in hours). <br/ ><br>Timepoint: During the Icu stay;5. Length of ICU stay. <br/ ><br>Timepoint: During the Icu stay;6. Mortality during ICU stay,Timepoint: During the Icu stay