Comparing the effectiveness of different concentrations of Ropivacaine(0.2%,0.33%,0.5%) with Dexamethasone as an adjunct used in scalp nerve block in relation to pain relief post-operatively and Intra-operative vitals stability in patients undergoing elective craniotomy.

Not Applicable

• Conditions: Health Condition 1: D330- Benign neoplasm of brain, supratentorialHealth Condition 2: O- Medical and Surgical

• Registration Number: CTRI/2023/06/053366
• Lead Sponsor: Dr BASUNDHARA CHAKRABARTI

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 26 June 2023

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Patients scheduled for elective craniotomy under general anesthesia planned for on-table extubation and expected to gain consciousness within 2 hrs.

1) American Society of Anaesthesiologists (ASA) physical

status of Iâ??II;

2) Age 18â??60 years;

3) Participants required to fix their head in a head clamp

intraoperatively;

4) Participants with an anticipated full recovery within 2

hrs postoperatively.

Exclusion Criteria

1) History of craniotomy;

2) Expected delayed extubation or no plan to extubate;

3) Participants who cannot understand the instructions

of a numeral rating scale (NRS) before surgery;

4) Extreme body mass index (BMI) ( <15 or >35); and body weight <50kg.

5) Allergy to opioids, dexamethasone, or ropivacaine;

6) History of excessive alcohol or drug abuse, chronic

opioid use (more than 2 weeks), or use of drugs with

confirmed or suspected sedative or analgesic effects;

7) History of psychiatric disorders, uncontrolled epilepsy

or chronic headache;

8) Pregnant or at breastfeeding;

9) Symptomatic cardiopulmonary, renal, or liver dysfunction

or history of diabetes;

10) Preoperative Glasgow Coma Scale <15;

11) Suspicion of intracranial hypertension;

12) Peri-incisional infection;

13) Participants who have received radiation therapy and

chemotherapy preoperatively or with a high probability

to require a postoperative radiation therapy and chemotherapy according to the preoperative imaging.

Study & Design

• Study Type: Interventional
• Study Design: Not specified