Change of microbiota of oral cavity, stomach and intestine by administration of lansoprazole and vonopraza
Phase 4
- Conditions
- Healthy volunteers
- Registration Number
- JPRN-UMIN000019998
- Lead Sponsor
- Shiga University of Medical Science Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Not provided
Exclusion Criteria
1. With medication of anti-microbial agents within three months. 2. With medication of anti-gastric acid inhibitory drug within three months. 3. With malignant diseases and severe complications 4. With mediaction of drug in relation with CYP3A4 pathway 5. With medication of corticosteroid 6. With active peptic ulcer 7. With severe complication, such as heart failure, renal failure and respiratory failure 8. With allergy for lansoprazole or vonoprazan 9. H. pylori-positive patients 10. Pregnancy 11. No informed consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes of microbiota in oral cavity, stomach and intestine between before and after administration of lansoprazole and vonoprazan
- Secondary Outcome Measures
Name Time Method (1) Change of serum gastrin level