Muscle wasting in chronic obstructive pulmonary disease (COPD): the role of resistance training and protein supplementatio

Completed

Conditions: Chronic obstructive pulmonary disease (COPD)
Respiratory
Other chronic obstructive pulmonary disease

Registration Number: ISRCTN22764439

Lead Sponsor: niversity Hospitals of Leicester NHS Trust (UK)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 120

Inclusion Criteria

For both COPD subjects and healthy control subjects:
1. Both males and females, aged between 50-85 years

COPD subjects:
1. Moderate-severe airflow obstruction (Forced expiratory volume in one second [FEV1] <50% predicted, FEV1/forced vital capacity [FVC] ratio <70%)
2. Reduced exercise tolerance (MRC grades III-V)
3. Stable
4. Able to carry out lower-limb resistance training

Healthy age-matched control subjects:
1. No evidence of airflow obstruction (FEV1 >80% predicted)
2. Able to carry out lower-limb resistance training

Exclusion Criteria

COPD subjects:
1. Long-term oral corticosteriods
2. Anticoagulant therapy or disorders
3. long term oxygen therapy (LTOT)
4. Diabetes
5. Co-morbid conditions preventing exercise training
6. Subects who have completed pulmonary rehabilitation in the previous 12-months

Healthy age-matched controls:
Same as for COPD subjects, also those who meet the criteria for fat-free mass depletion are excluded.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Muscle gene and protein expression (vastus lateralis needle biopsy samples) at baseline, 24 hours, 4 weeks and 8 weeks.

Secondary Outcome Measures

Name	Time	Method
1. Muscle strength (isometric and isokinetic quadriceps strength) at baseline, 4 weeks, 8 weeks and 6 months<br>2. Total body and quadriceps fat-free (muscle) mass (dual energy X-ray absorptiometry [DEXA]) at baseline, 4 weeks and 8 weeks<br>3. Circulating inflammatory cytokines (blood tests) at baseline, 24 hours, 4 weeks and 8 weeks<br>4. Whole-body exercise performance (incremental cycle ergometry test) at baseline and 8 weeks<br>5. Physical activity (questionnaire and activity monitor) at baseline and 8 weeks<br>6. Lung function and capillary blood gas tensions at baseline