Onthullen van moleculaire en cellulaire mechanismen die verband houden met veroudering van de schouderspieren en het optreden van een rotator cuff scheur.
Recruiting
- Conditions
- rotator cuff degeneration rotator cuff tears
- Registration Number
- NL-OMON20921
- Lead Sponsor
- eiden University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
MRI proven shoulder pathology for which shoulder surgery is needed.
Exclusion Criteria
- Age < 18 and > 80 years
- No informed consent
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method RNA profiling difference between subscapular and deltoid muscles and its correlation to magnetic resoncace imaging
- Secondary Outcome Measures
Name Time Method cell proliferation<br /><br>cell apoptosis<br /><br>mitochondrial activity<br /><br>cell fusion<br /><br>cell senescence<br /><br>Constant score<br /><br>Range of motion<br /><br>Muscle Strength<br /><br>DASH<br /><br>WORC<br /><br>MR features including: <br /><br>- fatty infiltration<br /><br>- cross sectional surface area<br>