nraveling the molecular and Cellular muscular mechanisms associated with Aging in rotator cuff Tears of the Shoulder

Completed

• Conditions: rotator cuff tear; 10028302

• Registration Number: NL-OMON41495
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

Patients undergoing MRI/CT evaluation of the shoulder. For biopsies collection, MRI/CT proven shoulder pathology for which shoulder surgery is needed. These will include, but not be limited to:
- Shoulder instability (primary)
- Rotator cuff tearing
- Osteoarthritis
- Fractures

Exclusion Criteria

- Age < 18 and > 80 years
- No informed consent
- Comorbidity: neurological disorders (stroke, M. Parkinson, dementia, muscle disease), rheumatoid arthritis, polymyalgia rheumatic, heart failure, COPD (Gold III-IV), chronic pain syndrome (fibromyalgia, complex regional pain syndrome etc)
- Metabolic diseases (e.g. insuline dependent DM)
- Cancer
- Medication: immunosuppressive drugs (e.g. prednisone, methotrexat, biologicals (TNF-alpha antagonists etc))
- Limited access to obtain muscle biopsies due to surgical exposure.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Growth capacity, Cell fusion, microarray (RNA)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>MRI/CT quantification (pathology, fatty infiltration, muscle atrophy), Clinical<br /><br>scores (Constant score, range of motion, muscle strength, VAS, DASH and WORC). </p><br>