Cardiac sympathetic nervous system function and activity as a predictor for appropriate implantable cardioverter defibrillator (ICD) therapy in patients with chronic heart failure.
Recruiting
- Conditions
- chronic heart failure, sympathetic cardiac activity, 123I-MIBG
- Registration Number
- NL-OMON21166
- Lead Sponsor
- Academic Medical Center, University of Amsterdam, the Netherlands
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 300
Inclusion Criteria
1. Left ventricular dysfunction (LVEF ≤35%) due to prior MI;
2. Left ventricular dysfunction (LVEF ≤35%) due to non-ischemic heart disease;
Exclusion Criteria
1. NYHA functional class IV at enrollment;
2. Coronary revascularization within the preceding three months;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Increased cardiac sympathetic activity and decreased sympathetic neuronal function as assessed by cardiac 123I-MIBG scintigraphy is associated with increased ICD discharge and anti-tachycardia pacing in patients with CHF and can therefore be used to identify patients who will most likely benefit from ICD implantation.
- Secondary Outcome Measures
Name Time Method