A study to compare the Magnesium sulphate nebulization versus intravenous infusion of Magnesium Sulphate in controlling post- intubation hemodynamic and stress response in adult patients undergoing scheduled surgeries.
- Conditions
- Medical and Surgical,
- Registration Number
- CTRI/2022/12/048494
- Lead Sponsor
- Department of anaesthesia and critical care
- Brief Summary
It is a comparative study of preoperative magnesium sulphate nebulization versus intravenous infusion of magnesium sulphate in controlling post- intubation hemodynamic and stress response in adult patients undergoing elective surgeries.
A total number of 130 patients between the age 18 to 65, undergoing elective surgeries will be assigned into 2 groups, group I and group N by Block randomization with sealed envelope system. There will be 65 patients in each group.
Group I will receive intravenous magnesium sulphate and group N will receive magnesium sulphate nebulization.
Primary objective will be to compare the changes in hemodynamic parameters between both groups in terms of Heart rate, Systolic blood pressure, Diastolic blood pressure, Mean arterial pressure, at different time intervals following laryngoscopy and intubation: Baseline (T0), Post intervention/pre-induction(T1), Just before laryngoscopy(T2), 1 min.post-intubation(T3), 3 min.post-intubation(T4), 5 min.post-intubation(T5), 10 min.post-intubation(T6)
Secondary objectives will be to compare : 1)Serum Cortisol level: Baseline and Post intubation (15 min) 2)Serum magnesium level:Baseline and Post intubation (15 min), between both groups.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 130
Both male and female between the age of 18 to 65 will be included.
- History of hypersensitivity to magnesium sulphate.
- Anticipated difficult airway.
- Patients on steroid therapy.
- Patients on psychiatric medication.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in Hemodynamic parameters following laryngoscopy and intubation in terms of: At different time intervals: | Baseline (T0) | Post intervention/pre-induction(T1) | Just before laryngoscopy(T2) | 1 min.post-intubation(T3) | 3 min.post-intubation(T4) | 5 min.post-intubation(T5) | 10 min.post-intubation(T6) 1)Heart rate At different time intervals: | Baseline (T0) | Post intervention/pre-induction(T1) | Just before laryngoscopy(T2) | 1 min.post-intubation(T3) | 3 min.post-intubation(T4) | 5 min.post-intubation(T5) | 10 min.post-intubation(T6) 2) Systolic blood pressure At different time intervals: | Baseline (T0) | Post intervention/pre-induction(T1) | Just before laryngoscopy(T2) | 1 min.post-intubation(T3) | 3 min.post-intubation(T4) | 5 min.post-intubation(T5) | 10 min.post-intubation(T6) 3)Diastolic blood pressure At different time intervals: | Baseline (T0) | Post intervention/pre-induction(T1) | Just before laryngoscopy(T2) | 1 min.post-intubation(T3) | 3 min.post-intubation(T4) | 5 min.post-intubation(T5) | 10 min.post-intubation(T6) 4)Mean arterial pressure At different time intervals: | Baseline (T0) | Post intervention/pre-induction(T1) | Just before laryngoscopy(T2) | 1 min.post-intubation(T3) | 3 min.post-intubation(T4) | 5 min.post-intubation(T5) | 10 min.post-intubation(T6)
- Secondary Outcome Measures
Name Time Method 1)Serum Cortisol level 2)Serum magnesium level
Trial Locations
- Locations (1)
Vardhman Mahavir Medical College and Safdarjung hospital
🇮🇳South, DELHI, India
Vardhman Mahavir Medical College and Safdarjung hospital🇮🇳South, DELHI, IndiaDR POOJA KUMARIPrincipal investigator9319304774kpooja004004@gmail.com