Validation of the Clinical and Antimicrobial Effectiveness of a Clorexidine and Sodium DNA Based Mouthwash in Patients With Stage III and IV Periodontitis
- Conditions
- Periodontitis
- Registration Number
- NCT06028867
- Lead Sponsor
- University of Catania
- Brief Summary
Sodium DNA has several properties that may be beneficial in the management of bacterial biofilm in periodontitis. The aim of this RCT study is to clinically evaluate the antimicrobial and oral biofilm control properties of two mouthwashes containing Chlorhexidine 0.12% + Sodium DNA and Chlorhexidine 0.20% at two weeks, compared with a placebo, on patients with stage III or IV periodontitis.
- Detailed Description
Sodium DNA has several properties that may be beneficial in the management of bacterial biofilm in periodontitis. The aim of this RCTstudy is to clinically evaluate the antimicrobial and oral biofilm control properties of two mouthwashes containing Chlorhexidine 0.12% + Sodium DNA and Chlorhexidine 0.20% at two weeks, compared with a placebo, on patients with stage III or IV periodontitis. The study was designed as a double-blind randomized controlled trial (RCT) with three parallel groups of individuals.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 56
• Clinically diagnosed with stage III or IV periodontitis according to the EFP/AAP 2017 criteria.
- Periodontal treatment, antibiotics, NSAIDs, immunosuppressants during the last 6 months.
- Pregnancy.
- Systemic diseases.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Subgingival biofilm 2 weeks Subgingival biofilm collected with sterile paper strips and analyzed by polimerase chain reaction
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
AOU Policlinico G. Rodolico
🇮🇹Catania, Italy
AOU Policlinico G. Rodolico🇮🇹Catania, Italy