Cellular Oxygen METabolism (COMET) measurements during cardiopulmonary bypass
- Conditions
- mitochondrial function during CPB10007593
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 37
Inclusion Criteria
- Age > 18 years
- Acceptable proficiency of the Dutch language
- 37 patients
- ASA 2-4 patients, in order to limit the influence of co-morbidities on the mitochondrial function.
- Cardiac surgery requiring CPB
Exclusion Criteria
- Presence of mitochondrial disease
- Pregnancy/ lactation
- emergency surgery,
- patients with intracardiac shunts
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- The mitoPO2 and mitoVO2 will be measured perioperatively. The mitoPO2 can be<br /><br>measured continuously with the COMET and will be defined in mmHg. For the<br /><br>mitoVO2 measurements, the local mitochondrial oxygen supply will be blocked by<br /><br>pressure on the skin. The mitoVO2 are then determined by the on-going oxygen<br /><br>usage inside the mitochondria over time. The mitoVO2 is defined as decline in<br /><br>the mitoPO2 over time; mmHg/s.<br /><br>- The tissue oxygen saturation is measured by the INVOSTM and is defined in<br /><br>percentage (%).</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Haematocrit is measured by standard care blood samples before, during and<br /><br>after CPB and is defined in volume percentage of the red blood cells in blood<br /><br>(vol%)<br /><br>- Throughout the operation and the first 24 hours on the ICU standard<br /><br>hemodynamic parameters, such as blood pressure (mmHg), heart rate (bpm), oxygen<br /><br>saturation (%), end tidal CO2 (kPa), temperture (Celsius) are measured and<br /><br>record every minute during the operation and every 15 minutes on the ICU. </p><br>