The effect of protein hydrolysate supplementation to preserve muscle mass during immobilisation and enhance muscle regain during recovery
- Conditions
- healthy, young subjects
- Registration Number
- NL-OMON24953
- Lead Sponsor
- uritas
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
1) Male
2) Aged 18-35 y
3) BMI 18.5-30.0 kg/m2
1) (Family) history of thrombosis
2) (Family) history of Factor V Leiden, or other known thrombophilia (such as; protein C, protein S, antithrombin deficiency)
3) Lower limb, back or shoulder injuries (which may interfere with the use of crutches)
4) Allergies to milk protein
5) Lactose intolerance
6) Participation in structured resistance exercise program
7) All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g., arthritis, spasticity/rigidity, all neurological disorders and paralysis)
8) Any medications known to (or may) affect protein metabolism (i.e., corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications)
9) Diagnosed diabetes
10) Diagnosed metabolic, cardiovascular or intestinal disorders
11) A history of neuromuscular problems
12) Use of anti-coagulants
13) Use of protein and/or fish-oil supplements
14) Participation in a 2H2O study in the previous 6 months.
15) Smoking
16) Any recent hospital admission/ major surgery
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method skeletal muscle mass (quadriceps muscle cross sectional area (CSA))
- Secondary Outcome Measures
Name Time Method maximal leg muscle strength (1RM), whole-leg muscle CSA, type I and II muscle fibre size, muscle protein synthesis rates, and muscle signalling and gene transcription responses