The effect of protein hydrolysate supplementation to preserve muscle mass during immobilisation and enhance muscle regain during recovery

Completed

Conditions: To assess muscle loss and muscle mass regain during immobilisation and recovery
muscle loss
muscle regain

Registration Number: NL-OMON55405

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

1) Male
2) Aged 18-35 y
3) BMI 18.5-30.0 kg/m2

Exclusion Criteria

(Family) history of thrombosis
Lower limb, back or shoulder injuries (which may interfere with the use of
crutches)
Allergies to milk protein
Participation in structured resistance exercise program
All co-morbidities interacting with mobility and muscle metabolism of the lower
limbs (e.g., arthritis, spasticity/rigidity, all neurological disorders and
paralysis)
Any medications known to (or may) affect protein metabolism (i.e.,
corticosteroids, non-steroidal anti-inflammatories, or prescription strength
acne medications)
Diagnosed metabolic, cardiovascular or intestinal disorders
A history of neuromuscular problems
Use of anti-coagulants
Smoking
(Family) history of Factor V Leiden or other known thrombophilia
Any recent hospital admission/ major surgery
diagnosed diabetes
use of protein and/or fish-oil supplements
participation in a 2H2O study in previous 6 months

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To determine the effect of protein hydrolysate supplementation on skeletal<br /><br>muscle mass (quadriceps muscle cross sectional area (CSA)) following 1 week of<br /><br>leg immobilisation.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To determine the effect of protein hydrolysate supplementation on maximal leg<br /><br>muscle strength (1RM), whole-leg muscle CSA, type I and II muscle fibre size,<br /><br>muscle protein synthesis rates, and muscle signalling and gene transcription<br /><br>responses after 1 week of immobilisation and after 2 weeks of recovery. </p><br>