Progressive Resistance Training and Cancer Testis (PROTRACT) - the effect of chemotherapy on the skeletal musculature in testicular cancer patients
Not Applicable
Completed
- Conditions
- Testicular CancerCancerMalignant neoplasm of testis
- Registration Number
- ISRCTN32132990
- Lead Sponsor
- The Faculty of Health Sciences, Copenhagen University (Denmark)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- 45
Inclusion Criteria
Testicular cancer patients (TCP), age 18-45, with advanced disease who are scheduled to start 3 cycles of BEP-treatment
Exclusion Criteria
1. Other previous or concurrent malignant disease
2. Cardiovascular disease
3. Chronic disease (ie. Diabetes)
4. Hypogonadism
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cellular muscle morphology will be assesed by muscle biopsies collected from m. vastus lateralis using the Bergstrom-technique. Muscle mean fibre area and fibre type distribution will be analysed by ATPase histo-chemistry.<br><br>The outcomes will be measured on the following time points <br>Baseline, before 1. cycle (0 weeks): Biopsy, Dual-emission X-ray absorptiometry (DXA) scan, strength test, blood sample, questionairres <br>Before 2. cycle (3 weeks): blood sample, questionairres <br>Before 3. cycle (6 weeks): blood sample, questionairres <br>Post treatment (9 weeks): biopsy, DXA scan, strength test, blood sample, questionairres <br>Follow up (21 weeks): DXA scan, strength test, blood sample, questionairres
- Secondary Outcome Measures
Name Time Method