Comparative Study Between Dexmedetomidine and Fentanyl as an Adjuvant to Intra-articular Bupivacaine for Postoperative Analgesia After Knee Arthroscopy.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Duration of postoperative analgesia
研究概览
简要总结
The aim of this study is to evaluate analgesic effects Bupivacaine, Bupivacaine plus Dexmedetomidine and Bupivacaine plus Fentanyl in relieving pain after knee arthroscopic surgery.
详细描述
Forty-five patients ASA I - II aged 21-45 years for elective knee arthroscopy were divided into 3 groups: Group B, BD and BF. Group B received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml saline. Group BD received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml dexmedetomidine (100 ug).
Group BF received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 fentanyl (50 ug). The time of first request of analgesia and analgesic effect by VAS during the first 24 hr. postoperatively are recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
anesthetist not sharing in the study will assess patient
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Either sex,
- •Age 21-45 years,
- •American Society of Anesthesia (ASA) I - II for elective knee arthroscopy.
排除标准
- •The patients with history of hepatic and renal diseases, psychiatric disorders,
- •Prolonged intake of (NSAIDS, opioids and tricyclic antidepressant),
- •Allergy to study drugs and patient who received analgesics up to 24 hr. before surgery were excluded from this study.
研究组 & 干预措施
group B
IGroup B received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml saline
干预措施: Bupivacain (Drug)
group BD
. Group BD received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml dexmedetomidine (100 ug).
干预措施: Dexmedetomidine (Drug)
group BD
. Group BD received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml dexmedetomidine (100 ug).
干预措施: Bupivacain (Drug)
group BF
Group BF received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 fentanyl (50 ug).
干预措施: Fentanyl (Drug)
group BF
Group BF received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 fentanyl (50 ug).
干预措施: Bupivacain (Drug)
结局指标
主要结局
Duration of postoperative analgesia
时间窗: For 24 hours postoperative
start from intra-articular injection of the drug to the time of first request of analgesia
次要结局
- total dose of rescue analgesia ( pethidine)(within 24 hours postoperative)
- pain intensity at rest (static)(at 24 hours postoperative)
- The number of participants with bradycardia, itching and hypotension(Within 24 hours postoperative)
- patient satisfaction(within 24 hours postoperative)
- pain intensity on mobilization of operated knee (dynamic)(at 24 hours postoperative)
研究者
Dina Abdelhameed Elsadek Salem
Principle investigator
Zagazig University