Comparison of intravenous and inhalational Dexmedetomidine in reducing response in terms of heart rate and blood pressure after laryngoscopy

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2021/11/038005
• Lead Sponsor: AIIMS Rishikesh

Brief Summary

This is a prospective, randomized, double-blinded, study to compare effectiveness of preoperative Inhalational Dexmedetomidine with Intravenous Dexmedetomidine in reducing the hemodynamic response to laryngoscopy among patients undergoing endotracheal intubation for elective surgery under general anaesthesia. the primary outcome is to compare the Mean Arterial Pressure and Heart Rate changes following laryngoscopy between the study groups at specific time intervals. Secondary outcome is to compare preinduction hemodynamics and sedation following  administration of Dexmedetomidine and to compare the propofol consumption during induction among the studied groups. ASA-I/II, aged 18-60 patients undergoing elective surgery requiring endotracheal intubation will be included. Total included patient are 130, 65 patients in each group.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-11-11
• Study Start: 2021-11-15

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

ASA I and II Patients undergoing elective surgery under general anaesthesia requiring endotracheal intubation.

Exclusion Criteria

• 1.Anticipated Difficult laryngoscopy and intubation or more than one attempt for intubation taken.
• 2.Patient having cardiovascular dysfunction.
• 3.Pre-existing hepatic or renal impairment.
• 4.Pregnant patients.
• 5.Patient refusal for consent.
• 6.Allergic to Study Drug.
• 7.Uncontrolled Hypertensive 8.Patients with raised intracranial pressure.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the Mean Arterial Pressure and Heart rate changes following laryngoscopy between the study groups.	at laryngoscopy, just after intubation, 1, 5, 10 min following intubation

Secondary Outcome Measures

Name	Time	Method
To compare the propofol consumption during induction among the studied groups	dose of propofol will be calculated after completion of laryngoscopy and intubation
To compare preinduction hemodynamics and sedation following	administration of Dexmedetomidine.

Trial Locations

Locations (1)

Department of anesthesia, main OT complex level 6, AIIMS Rishikesh; 🇮🇳 Dehradun, UTTARANCHAL, India

Department of anesthesia, main OT complex level 6, AIIMS Rishikesh

🇮🇳Dehradun, UTTARANCHAL, India

Dr Priyanka Gupta

Principal investigator

09811894899

drpriyankagupta84@gmail.com