Accuracy and Precision of Train-of-Four Ratios Obtained With Acceleromyography and Electromyography in Restricted-Movement Settings in the Absence of Neuromuscular Blocking Drugs

• Conditions: Cystoscopy

• Registration Number: NCT06805032
• Lead Sponsor: Mayo Clinic

Brief Summary

The purpose of this research is to compare the performance of acceleromyograph and electromyograph-based quantitative neuromuscular monitors when the arms are tucked for surgical positioning.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2025-01-28
• Study First Submitted QC: 2025-01-28
• Study First Posted: 2025-02-03
• Study Start: 2025-03-25
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-09
• Last Update Posted: 2025-04-11
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patients willing to participate and provide an informed consent.
• Patients undergoing elective surgical procedures that require general anesthesia without use of NMBA agents administered intraoperatively, and tucked arms.
• Anticipated surgery duration < 120 minutes.

Exclusion Criteria

• Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury.
• Patients with systemic neuromuscular diseases such as myasthenia gravis.
• Patients having surgery that would involve prepping the arm into the sterile field.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Accuracy and precision	120 minutes	Accuracy and precision of train-of-four ratios measured simultaneously by two quantitative neuromuscular monitors every minute among 40 patients undergoing surgery of at least 30 min duration (roughly 1200 measurements) in which the arms are tucked and in the absence of neuromuscular blocking agents. In the absence of neuromusuclar blocking agents, the expected train-of-four ratio is 1.0. Accuracy of each monitor will be assessed by how close measuremetns are to 1.0 while precision will be assessed by the variability of the measured responses in all patients undergoing procedure.

Trial Locations

Locations (1)

Mayo Clinic; 🇺🇸 Jacksonville, Florida, United States