The Change of NK Cell Activity After Head and Neck Cancer Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 试验地点
- 1
- 主要终点
- The change of NK cell activity
研究概览
简要总结
Cellular immunity can be changed after surgery and anesthesia. Tissue injury by surgical procedures significantly reduces the immune function in proportion to the degree of tissue injury. In addition, the use of opioids as analgesics during the perioperative period depress cellular immunity, in particular the activity of the natural killer (NK) cells. This perioperative immunosuppression may cause deleterious consequences on postoperative outcome in cancer patients. The aim of this study is to confirm the presence or extent of the change of NK cell activity between before and after head and neck surgery. Additionally, investigators will identify the clinical or genetic factors related to the change of NK cell activity.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The patients undergoing head and neck surgery including tumor removal and reconstruction with flap
排除标准
- •patients refusal
- •patients not able to read, or understand the consent form
- •History of Active viral or bacterial infection
- •History of use of immunosuppressive drugs within the last six months
- •History of chemotherapy
- •History of autoimmune disorders
- •Known HIV, Hepatitis B, or Hepatitis C infection
- •Female who is pregnant, nursing
- •ethnicity, other than asian
结局指标
主要结局
The change of NK cell activity
时间窗: 24 hours
Preoperative NK cell activity will be measured using the NK vue diagnostic test before surgery and anesthesia. Postoperative NK cell activity will be measured using the NK vue diagnostic test after 24 hours since stopping the use of intravenous remifentanil as analgesics during anesthesia in the operating room or sedation in the intensive care unit.
次要结局
未报告次要终点