Effect of alpha lipoic acid on methotrexate-induced hepatotoxicity in children with acute lymphoblastic leukemia
Phase 4
Recruiting
- Conditions
- Cancer
- Registration Number
- PACTR202208655573502
- Lead Sponsor
- aculty of medicine of tanta university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Children of newly diagnosed acute lymphoblastic leukemia
Exclusion Criteria
patients with history of liver disease or active hepatitis (serum transaminases more than three times the upper limit of normal), potential exposure to agents capable of damaging the liver (such as heavy metals or solvents), regular consumption of drugs other than MTX with potential hepatotoxicity, renal impairment (serum creatinine more than twice the upper limit of normal), sepsis or active infection, relapse or secondary malignancy, serious complications that may necessitate cessation of chemotherapy for undetermined duration will be excluded in our study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method