Genetic aspects of Barrett Esophagus

• Conditions: Barrett Esophagus; 10017969; 10017991

• Registration Number: NL-OMON31201
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 1500

Inclusion Criteria

Patients:
- Age >= 18 years
- Informed consent
- Participating in the CYBAR study ( histological confirmation of diagnosis of BE);Family members:
- Age >= 18 years
- Informed consent

Exclusion Criteria

- Unable to fill out questionnaire

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>•Familial incidence of GERD, BE and EAC in first en second degree relatives of<br /><br>patients with BE in the Netherlands.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>•Gene-environment interactions on familial susceptibility to GERD and BE<br /><br>•Incidence of EAC in family members of patients with GERD and BE.<br /><br>•Reported polymorphisms in BE are predictive for developing BE in relatives of<br /><br>patients with this disorder.</p><br>