Exercise Substrate Utilisation and Endurance Performance Following Short-term Manipulation of Dietary Fat Intake in Women
试验速览
- 阶段
- 不适用
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Rates of fat oxidation during exercise
研究概览
简要总结
The capacity to burn fat as fuel for exercise may have important implications for sporting performance, with dietary fat intake positively influencing this ability.
Endurance performance and the ability to burn fat will be measured in women runners following the consumption of 3 diets varying in the amount of fat and carbohydrate.
详细描述
Dietary fat intake positively influences the ability to burn fat during exercise in women but not men, whereas carbohydrate intake negatively influences fat oxidation in both sexes. The independent nature of dietary fat intake as a predictor of the ability to burn fat in women suggests that in conditions of adequate carbohydrate intake providing additional fat may increase fat oxidation in women whereas it does not in men. It is of interest to explore if indeed women are responsive (i.e., increase in fat oxidation) to short-term increases in dietary fat intake induced by overfeeding (adequate carbohydrate) or if as appears to be the case in men reduced carbohydrate intake as typically employed in high-fat, low carbohydrate dietary studies is also a prerequisite for enhancing fat oxidation in women, and whether this translates into a difference in exercise endurance performance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •BMI >17.0 < 25 kg/m2
- •Good General Health
- •Accustomed to vigorous physical activity
- •Run > 2 times per week
- •V̇O2max >50ml/kg/min
- •Weight Stable > last 6months
- •Non Smoker
- •Pre-menopausal, and either eumenorrheic and regularly menstruating, or using monophasic hormonal oral contraceptives for > 3 months.
排除标准
- •Currently taking part in another scientific/clinical study
- •Taking any prescription drug / supplement thought to influence metabolism
- •Following unusual dietary practices (such as intermittent fasting or low carbohydrate diets)
- •Breast Feeding
结局指标
主要结局
Rates of fat oxidation during exercise
时间窗: 90 minutes of sub-maximal exercise
Rates of fat oxidation to be measured via indirect calorimetry during 90 minutes of submaximal exercise
次要结局
- Change in Free Fatty Acid concentration(90 minutes sub-maximal exercise)
- 5km running performance(Immediately following measurement of Primary Outcome measure)
- Change in plasma glucose concentration(90 minutes sub-maximal exercise)
- Change in plasma glycerol concentration(90 minutes sub-maximal exercise)
