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临床试验/NCT02568592
NCT02568592Unknown不适用

Exercise Substrate Utilisation and Endurance Performance Following Short-term Manipulation of Dietary Fat Intake in Women

University of Birmingham2 个研究点 分布在 1 个国家目标入组 16 人开始时间: 2015年3月最近更新:
适应症

试验速览

阶段
不适用
入组人数
16
试验地点
2
主要终点
Rates of fat oxidation during exercise

研究概览

简要总结

The capacity to burn fat as fuel for exercise may have important implications for sporting performance, with dietary fat intake positively influencing this ability.

Endurance performance and the ability to burn fat will be measured in women runners following the consumption of 3 diets varying in the amount of fat and carbohydrate.

详细描述

Dietary fat intake positively influences the ability to burn fat during exercise in women but not men, whereas carbohydrate intake negatively influences fat oxidation in both sexes. The independent nature of dietary fat intake as a predictor of the ability to burn fat in women suggests that in conditions of adequate carbohydrate intake providing additional fat may increase fat oxidation in women whereas it does not in men. It is of interest to explore if indeed women are responsive (i.e., increase in fat oxidation) to short-term increases in dietary fat intake induced by overfeeding (adequate carbohydrate) or if as appears to be the case in men reduced carbohydrate intake as typically employed in high-fat, low carbohydrate dietary studies is also a prerequisite for enhancing fat oxidation in women, and whether this translates into a difference in exercise endurance performance.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 45 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • BMI >17.0 < 25 kg/m2
  • Good General Health
  • Accustomed to vigorous physical activity
  • Run > 2 times per week
  • V̇O2max >50ml/kg/min
  • Weight Stable > last 6months
  • Non Smoker
  • Pre-menopausal, and either eumenorrheic and regularly menstruating, or using monophasic hormonal oral contraceptives for > 3 months.

排除标准

  • Currently taking part in another scientific/clinical study
  • Taking any prescription drug / supplement thought to influence metabolism
  • Following unusual dietary practices (such as intermittent fasting or low carbohydrate diets)
  • Breast Feeding

结局指标

主要结局

Rates of fat oxidation during exercise

时间窗: 90 minutes of sub-maximal exercise

Rates of fat oxidation to be measured via indirect calorimetry during 90 minutes of submaximal exercise

次要结局

  • Change in Free Fatty Acid concentration(90 minutes sub-maximal exercise)
  • 5km running performance(Immediately following measurement of Primary Outcome measure)
  • Change in plasma glucose concentration(90 minutes sub-maximal exercise)
  • Change in plasma glycerol concentration(90 minutes sub-maximal exercise)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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