Effects of Exercise Mode on Cardiac Fat and Function
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Changes in Epicardial adipose tissue (EAT)
研究概览
简要总结
The overall goal of this project is to study the effects of exercise energy expenditure matched vigorous dynamic resistance training and aerobic training on cardiac fat, and its relationship to cardiac function and geometry using cardiac Magnetic Resonance Imaging.
详细描述
Exercise-induced weight-loss is one of the most common strategies for reducing excess fat in overweight and obese individuals. Although vigorous intensity may be more favorable promoting positive cardiac adaptations compared to low-moderate intensity, evidence of the positive effects of different exercise modes needs to be explored to allow for realistic comparisons with other strategies. Research using cardiac Magnetic Resonance Imaging that compares the effects of different modes of exercise - matched by exercise energy expenditure - on epicardial adipose tissue and paracardial adipose tissue, and how these interventions modify cardiac function and geometry have not been previously explored in obesity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Sedentary
- •Caucasian
- •BMI >30 kg/m2 and < 39.9 kg/m2
排除标准
- •Known cardiovascular, metabolic, pulmonary disease or conditions
- •Muscular-skeletal injuries
- •Taking medications that affect endocrine or cardiovascular function
- •Hypertension
- •Being engaged in low intensity strength training more than two times per week or moderate-high intensity of any type of frequency
- •Being pregnant
- •Cigarette smoking
- •Having non-removable pieces or devices incompatible with DXA and CMR assessment.
结局指标
主要结局
Changes in Epicardial adipose tissue (EAT)
时间窗: 2 assessment points: at baseline and week 4
EAT will be measured using cardiac Magnetic Resonance
Changes in Vascular Health
时间窗: 2 assessment points: at baseline and week 4
Atrial stiffness will be measured using a pulse wave analysis
次要结局
- Changes in Muscular Strength(2 assessment points: at baseline and week 4)
- Changes in Paracardial adipose tissue (PAT)(2 assessment points: at baseline and week 4)
- Changes in Cardiorespiratory Function(2 assessment points: at baseline and week 4)
- Changes in Body Composition(2 assessment points: at baseline and week 4)