Effects of Exercise Mode on Cardiac Fat and Function

Not Applicable

Terminated

• Conditions: Obesity

• Registration Number: NCT03297333
• Lead Sponsor: Southern Illinois University Edwardsville

Brief Summary

The overall goal of this project is to study the effects of exercise energy expenditure matched vigorous dynamic resistance training and aerobic training on cardiac fat, and its relationship to cardiac function and geometry using cardiac Magnetic Resonance Imaging.

Detailed Description

Exercise-induced weight-loss is one of the most common strategies for reducing excess fat in overweight and obese individuals. Although vigorous intensity may be more favorable promoting positive cardiac adaptations compared to low-moderate intensity, evidence of the positive effects of different exercise modes needs to be explored to allow for realistic comparisons with other strategies. Research using cardiac Magnetic Resonance Imaging that compares the effects of different modes of exercise - matched by exercise energy expenditure - on epicardial adipose tissue and paracardial adipose tissue, and how these interventions modify cardiac function and geometry have not been previously explored in obesity.

Study Timeline

• Study First Submitted: 2017-09-26
• Study First Submitted QC: 2017-09-28
• Study First Posted: 2017-09-29
• Study Start: 2017-10-01
• Status Verified: 2019-07
• Primary Completion: 2020-03-16
• Study Completion: 2020-03-16
• Last Update Submitted: 2021-09-27
• Last Update Posted: 2021-10-04

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Female
• Target Recruitment: 18

Inclusion Criteria

• Sedentary
• Caucasian
• BMI >30 kg/m2 and < 39.9 kg/m2

Exclusion Criteria

• Known cardiovascular, metabolic, pulmonary disease or conditions
• Muscular-skeletal injuries
• Taking medications that affect endocrine or cardiovascular function
• Hypertension
• Being engaged in low intensity strength training more than two times per week or moderate-high intensity of any type of frequency
• Being pregnant
• Cigarette smoking
• Having non-removable pieces or devices incompatible with DXA and CMR assessment.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Changes in Epicardial adipose tissue (EAT)	2 assessment points: at baseline and week 4	EAT will be measured using cardiac Magnetic Resonance
Changes in Vascular Health	2 assessment points: at baseline and week 4	Atrial stiffness will be measured using a pulse wave analysis

Secondary Outcome Measures

Name	Time	Method
Changes in Muscular Strength	2 assessment points: at baseline and week 4	Muscular Strength will be assessed by 1 repetition maximum (1RM) test
Changes in Paracardial adipose tissue (PAT)	2 assessment points: at baseline and week 4	PAT will be measured using cardiac Magnetic Resonance
Changes in Cardiorespiratory Function	2 assessment points: at baseline and week 4	Cardiorespiratory Function will be measured on a treadmill with a metabolic cart
Changes in Body Composition	2 assessment points: at baseline and week 4	Body composition will be measured using dual-energy x-ray absorptiometry

Trial Locations

Locations (1)

Southern Illinois University of Edwardsville; 🇺🇸 Edwardsville, Illinois, United States