Effects of Exercise Mode on Cardiac Fat and Function
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obesity
- Sponsor
- Southern Illinois University Edwardsville
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Changes in Epicardial adipose tissue (EAT)
- Status
- Terminated
- Last Updated
- 4 years ago
Overview
Brief Summary
The overall goal of this project is to study the effects of exercise energy expenditure matched vigorous dynamic resistance training and aerobic training on cardiac fat, and its relationship to cardiac function and geometry using cardiac Magnetic Resonance Imaging.
Detailed Description
Exercise-induced weight-loss is one of the most common strategies for reducing excess fat in overweight and obese individuals. Although vigorous intensity may be more favorable promoting positive cardiac adaptations compared to low-moderate intensity, evidence of the positive effects of different exercise modes needs to be explored to allow for realistic comparisons with other strategies. Research using cardiac Magnetic Resonance Imaging that compares the effects of different modes of exercise - matched by exercise energy expenditure - on epicardial adipose tissue and paracardial adipose tissue, and how these interventions modify cardiac function and geometry have not been previously explored in obesity.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Sedentary
- •Caucasian
- •BMI \>30 kg/m2 and \< 39.9 kg/m2
Exclusion Criteria
- •Known cardiovascular, metabolic, pulmonary disease or conditions
- •Muscular-skeletal injuries
- •Taking medications that affect endocrine or cardiovascular function
- •Hypertension
- •Being engaged in low intensity strength training more than two times per week or moderate-high intensity of any type of frequency
- •Being pregnant
- •Cigarette smoking
- •Having non-removable pieces or devices incompatible with DXA and CMR assessment.
Outcomes
Primary Outcomes
Changes in Epicardial adipose tissue (EAT)
Time Frame: 2 assessment points: at baseline and week 4
EAT will be measured using cardiac Magnetic Resonance
Changes in Vascular Health
Time Frame: 2 assessment points: at baseline and week 4
Atrial stiffness will be measured using a pulse wave analysis
Secondary Outcomes
- Changes in Muscular Strength(2 assessment points: at baseline and week 4)
- Changes in Paracardial adipose tissue (PAT)(2 assessment points: at baseline and week 4)
- Changes in Cardiorespiratory Function(2 assessment points: at baseline and week 4)
- Changes in Body Composition(2 assessment points: at baseline and week 4)