Can Neurally Adjusted Ventilatory Assist Mode Reduce Mechanical Ventilation Day in Patients With Chronic Obstructive Pulmonary Disease ?
Overview
- Phase
- Not Applicable
- Intervention
- conventional group
- Conditions
- Obstructive Lung Diseases
- Sponsor
- Fu Jen Catholic University Hospital
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- ventilator-free days(VFDs)
- Status
- Completed
- Last Updated
- 2 months ago
Overview
Brief Summary
Background： Neurally Adjusted Ventilatory Assist (NAVA) mode is a new mode of ventilator, using electronic potential of diaphragm to adjust tidal volume. At the same time, this mode can trigger and cycle-off inspiratory time by high sensitivity of electronic potential of diaphragm, increase patient-ventilator synchrony, reduce sedative drug, improve oxygenation, shorten mechanical ventilation day and reduce the rate of diaphragm atrophy. It can improve survival rate and hospital day of patients. Both the animal and human experiment have the effect of lung and diaphragm protection Effect： The results of this trial are expected to obtain electronic potential of diaphragm in patients with obstructive pulmonary disease. Reviewing the current literature, few related literatures have such data presentation. This trial hopes to evaluate whether the use of NAVA can reduce mechanical ventilation day by analyzing electronic potential of diaphragm in patients with obstructive pulmonary disease.
Investigators expect that participants with obstructive pulmonary disease using NAVA mode will have significantly less mechanical ventilation day than using conventional mode
Investigators
Eligibility Criteria
Inclusion Criteria
- •Obstructive pulmonary diseases include chronic obstructive pulmonary disease (COPD), asthma (Asthma), cystic fibrosis (cystic fibrosis), bronchiectasis (bronchiectasis), bronchiolitis or other diseases that cause airway stenosis, etc.
- •Other patients with obstructive pulmonary disease assessed by the clinical team
- •Consent signed by the principal or legal representative
- •Age \> 20 years old and \< 99 years old
Exclusion Criteria
- •Those who cannot place a nasogastric tube due to medical conditions
- •Pregnant women
- •Those who have received gas cutting
- •Patients with phrenic nerve palsy
- •Neuromuscular disease
- •Intubation due to cardiac arrest
Arms & Interventions
conventional group
Using conventional mode to compare mechanical ventilation day with experimental group
experimental group
Using neurally adjusted ventilatory assist mode to compare mechanical ventilation day with conventional group
Intervention: Ventilator mode
Outcomes
Primary Outcomes
ventilator-free days(VFDs)
Time Frame: up to 28 days
Each day during the measurement period that participants are both alive and free of mechanical ventilation. A participants who is extubated on Day 2 of the study and remains alive and free of the ventilator for the remainder of the 28-day study period.