Sleep Restriction and Parental History of Hypertension
- Conditions
- Hypertension
- Interventions
- Behavioral: Partial sleep deprivation (sleep restriction)Behavioral: Normal sleep
- Registration Number
- NCT06482814
- Lead Sponsor
- Mayo Clinic
- Brief Summary
The purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood pressure compared to a group of individuals whose parents have normal blood pressure.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 44
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Study Sequence AB Partial sleep deprivation (sleep restriction) Sleep restriction condition in the first period and normal sleep condition in the second period. Each period will consist of a 10-day inpatient visit comprising a 3-day/2-night baseline, followed by a 5-day/5-night experimental phase, and a 2-day/2-night recovery phase. Study Sequence BA Normal sleep Normal sleep condition in the first period and sleep restriction condition in the second period. Each period will consist of a 10-day inpatient visit comprising a 3-day/2-night baseline, followed by a 5-day/5-night experimental phase, and a 2-day/2-night recovery phase. Study Sequence AB Normal sleep Sleep restriction condition in the first period and normal sleep condition in the second period. Each period will consist of a 10-day inpatient visit comprising a 3-day/2-night baseline, followed by a 5-day/5-night experimental phase, and a 2-day/2-night recovery phase. Study Sequence BA Partial sleep deprivation (sleep restriction) Normal sleep condition in the first period and sleep restriction condition in the second period. Each period will consist of a 10-day inpatient visit comprising a 3-day/2-night baseline, followed by a 5-day/5-night experimental phase, and a 2-day/2-night recovery phase.
- Primary Outcome Measures
Name Time Method 24-hour Systolic Blood Pressure (BP) Day 2, Day 4, Day 7, and Day 9 Systolic Blood pressure will be measured in mmHg
- Secondary Outcome Measures
Name Time Method 24-hour Diastolic blood pressure (DBP) Day 2, Day 4, Day 7, and Day 9 Diastolic blood pressure will be measured in mmHg
Asleep Systolic Blood Pressure/Diastolic Blood Pressure (SBP/DBP) Day 2, Day 4, Day 7, and Day 9 Asleep SBP/DBP will be measured in mmHg/mmHg
Systolic Blood Pressure/Diastolic Blood Pressure (SBP/DBP) Nocturnal dipping Day 2, Day 4, Day 7, and Day 9 SBP/DBP Nocturnal dipping will be measured in percent (%)
Baroreflex Sensitivity Day 3, Day 5, Day 8, and Day 10 Baroreflex Sensitivity will be measured from simultaneous electrocardiography (ECG) and noninvasive beat-to-beat BP recording.
Catecholamines Day 2, Day 4, Day 7, and Day 9 Catecholamines will be measured from a 24-hour urine collection.
Blood Pressure (BP) response to stressors Day 3, Day 5, Day 8, and Day 10 BP response to stressors will be measured in mmHg
DNA-methylation Day 3, Day 5, Day 8, and Day 10 Methylated gene markers in peripheral blood mononuclear cells will be obtained
Awake Systolic Blood Pressure/Diastolic Blood Pressure (SBP/DBP) Day 2, Day 4, Day 7, and Day 9 Awake SBP/DBP will be measured in mmHg/mmHg
Endothelial Function Day 3, Day 5, Day 8, and Day 10 Endothelial function will be estimated from flow-mediated vasodilation using ultrasound.
Heart Rate response to stressors Day 3, Day 5, Day 8, and Day 10 Heart Rate response to stressors will be measured by ECG
Transcriptomic Day 3, Day 5, Day 8, and Day 10 Whole transcriptome in peripheral blood mononuclear cells will be obtained
Trial Locations
- Locations (1)
Mayo Clinic in Rochester
🇺🇸Rochester, Minnesota, United States