Impact of bariatric surgery on both central serotonin- and norepinephrine transporter (SERT/ NET) availability in obese subjects using positron emission tomography (PET) and selective radio-labelled marker before and 6 months after surgery
- Conditions
- E66F50ObesityEating disorders
- Registration Number
- DRKS00003571
- Lead Sponsor
- niversitätsklinikum Leipzig AöRKlinik und Poliklinik für Nuklearmedizin
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 27
• Age between 18 and 70
• BMI > 40 kg/m2
• no psychotropic-medication and/or drugs for at least 8 weeks prior PET
• written informed consent
• History of neurological or psychiatric diseases
• Structural lesions (stroke, traumatic brain injury etc.)
• Cognitive deficits, major speech impairment, alcohol- or drug abuse (positive drug test)
• Major mental disorders, major communicative deficiencies which inhibit an informed consent
• neurosurgical interventions in the past
• migraine
• Epilepsy, cerebral seizures in previous medical history (or in history of the family)
• Chronic diseases (e.g. asthma) indicating chronic medical treatment with central effect
• Pregnancy
• Contraindications for MR imaging (e.g., implanted ferro-magnetic devices), claustrophobia
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method quantified central SERT /NET availability (binding-potential BP and distribution volume [ratios] DV[R]) in obese patients (BMI = 40 kg/m2) undergoing bariatric surgery before and afterwards.
- Secondary Outcome Measures
Name Time Method Correlation of BP and DVR values with the following parameters: genotype, stress reaction, age, gender. Comparison of the obese subjects before and 6 month after bariatric surgery.