Impact of bariatric surgery on neural food processing and cognition – an fMRI study
- Conditions
- E66Obesity
- Registration Number
- DRKS00012495
- Lead Sponsor
- Fakultät VI - Medizin und Gesundheitswissenschaften Carl-von Ossietzky Universität Oldenburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Female
- Target Recruitment
- 50
Inclusion Criteria
Age: 18-60
BMI: >35kg/m2 (Obesity-Group); <25kg/m2 (Control-Group)
Gender: Female
Participants in the obesity group will receive RYGB operation
Exclusion Criteria
Substance abuse
Smoking
Psychiatric disorders (except anxiety)
History of eating disorder
Psychopharmacological treatment
Pregnancy
Claustrophobia
Neurological disorders
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Neuronal food porcessing - presentation via food-images - measured with fMRI<br>2. working memory - presentation with 2-back-task - measured with fMRI<br>3. functional connectivity - measurement at rest with fMRI<br><br>All measurements will be done twice (pre-surgery and one year post-surgery)
- Secondary Outcome Measures
Name Time Method 1. hormonal status (GLP-1, PYY)<br>2. working memory results from the 2-back-task (hits, erros, false postives)<br>3. questionnaire data (Freiburg Personality Inventory, structured clinical interview, questionnaire if eating behavior, Beck Depression Inventory, Behavioral Inhibtion System, Wender-Utah-rating scales, Conners' adult ADHD self-rating scales)<br><br>All measurements will be done twice (pre-surgery and one year post-surgery)<br><br>