A double blind clinical trial of intravenous caffeine in accelerating awakening from total intravenous anesthesia
Phase 2
- Conditions
- Awakening from general anethesia.
- Registration Number
- IRCT2016021725600N2
- Lead Sponsor
- Vice chancellor for research, Urmia University Of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Male and female ASA class I and II patients aged 20 to 50 scheduled for elective laparoscopic cholecystectomy using total intravenous anesthesia(TIVA)
Exclusion criteria: Age above 20 and under 50 years old; ASA class >II; opioids, caffeine or caffeine containing drinks use during 8 hours before surgery; history of psychologic disorders, epilepsy, antipsychotic or antiepileptic drugs use; hepatic or cardiac diseases.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The time interval between BIS value 80 untill BIS=60 after IV anesthetic infusion. Timepoint: Immediately after stopping IV anesthetic infusion. Method of measurement: Chronometer as second.;The time interval between BIS value 80 untill endotracheal extubation. Timepoint: Immediately after stopping IV anesthetic infusion. Method of measurement: Chronometer as second.;The time interval between BIS value 80 untill Patient's eyes opening. Timepoint: Immediately after stopping IV anesthetic infusion. Method of measurement: Chronometer as second.;Short Orientation Memory Concentration Test Score. Timepoint: 30 minutes after endotracheal extubation. Method of measurement: Short Orientation Memory Concentration Test.
- Secondary Outcome Measures
Name Time Method Postoperative nausea and vomiting. Timepoint: After end of anesthesia and during stay in recovery unit. Method of measurement: By monitoring of the patient's symptoms and asking.;Mean IV anesthetic infusion dose during anesthesia in intervention and control groups. Timepoint: During maintenance of anesthesia. Method of measurement: Calculating of mean maintenance infusion dose of anesthetics as microgram per kilogram of body weight per minute.