NCT04274231Unknown不适用
Integrative Genomic Analysis Reveals Cancer-associated Gene Mutations in Chronic Myeloid Leukemia Patients With Tyrosine Kinase Inhibitor Resistance or Intolerance
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- cancer-associated gene mutations in CML treatment with TKIs by NGS
研究概览
简要总结
We performed targeted-capture sequencing of 127 known and putative cancer-related genes of patients who best effect to TKIs ,or intolerance to TKIs,or resistance to TKIs by next-generation sequencing (NGS) .
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chronic myeloid leukemia-Chronic phase(CML-CP) patients treated with receiveTyrosine kinase inhibitor -TKI(including imatinib, dasatinib and nilotinib) for more than 1 years
- •best effect to TKIs ,or intolerance to TKIs,or resistance to TKIs according to Q-pcr detected BCR/ABL(IS) in peripheral blood and hematologic response and cytogenetic response
- •Informed consent of the patient or his legal representative
排除标准
- •Patients had history of CML-AP or CML-BC
- •CML Patients who have received allogeneic hematopoietic stem cell transplantation
- •CML Patients who have received immunotherapy (except interferon, including car-t and other cellular immunotherapy)
- •Woman who is pregnant or nursing
结局指标
主要结局
cancer-associated gene mutations in CML treatment with TKIs by NGS
时间窗: 1 year after TKI treatment
We performed targeted-capture sequencing of 127 known and putative cancer-related genes of patients who best effect to TKIs ,or intolerance to TKIs,or resistance to TKIs by next-generation sequencing (NGS)
次要结局
未报告次要终点
研究者
xuna
doctor
Nanfang Hospital, Southern Medical University
研究点 (1)
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