Motor, Non-motor and Genetic Determinants of Progression and Complications in Parkinson's Disease: A Multicenter Cohort Study in Mexican Population (ReMePArk)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 550
- 试验地点
- 6
- 主要终点
- To assess motor scale change over time
研究概览
简要总结
The objective of the study is to assess the effect of motor, non-motor and genetic factors on the progression of Parkinson's disease as well as its impact on complications rates.
A large sample of Mexican subjects with Parkinson's disease attending several referral centers will be included.
Data collected will include disease severity and motor scales, non-motor scales as well as genotyping for monogenic forms of the disease.
Assessments will be performed every 6 months for two years.
详细描述
Demographic and clinical data will be collected after obtaining a signed informed consent.
Recruitment will be competitive. Data collected includes age, gender, motor phenotype, age at onset, age at diagnosis, smoking history, family history, antiparkinsonic treatment, other treatments and a complete neurological evaluation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of Parkinson's disease by the United Kingdom Parkinson's disease Society Brain Bank Criteria
- •Any gender
- •Any Hoehn and Yahr stage
- •Written informed consent
排除标准
- •Severe comorbidity that may limit proper neurological evaluation as judged by the investigator
- •Subjects with atypical or secondary parkinsonism
结局指标
主要结局
To assess motor scale change over time
时间窗: Every 6 months for 2 years
Motor symptoms will be assessed by proper and validated motor scales; also minimal clinically important change will be determined.
次要结局
- To assess caregiver burden as disease progresses(Every 12 months for 2 years)
- To assess quality of life change over time.(Every 6 months for 2 years)
- To assess non-motor symptoms over time(Every 6 months for 2 years)
研究者
Amin Cervantes-Arriaga
MD, MSc
El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez