Impact of dexmedetomidine on postoperative biomarkers, length of hospitalisation and mortality in patients undergoing coronary artery bypass graft su

Not Applicable

• Conditions: Circulatory System; cardiovascular disease

• Registration Number: PACTR201806003460336
• Lead Sponsor: Palesa Mot

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-06-12
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

1.Left main or triple vessel coronary artery disease.
2.Age above 18 and below 65 years.

Exclusion Criteria

1.Age below 18 or above 65 years.
2.Pregnancy or lactation.
3.Liver dysfunction (AST or ALT > twice the upper range of normal). Normal values (National Health Laboratory Services: AST 5¿40 and ALT 5¿40 units/dl).
4.Sick sinus syndrome.
5.Use of concomitant medication with potential for major drug interactions such as propoxyphene, sodium oxybate and tinazide.
6.Patients requiring preoperative inotropic support.
7.Asthma.
8.Uncontrolled pulmonary congestion as evidenced radiologically and by arterial hypoxemia.
9.Evidence of ongoing infection as indicated by acute phase reaction markers.
10.Patients undergoing combined coronary and valve surgery, or other open heart procedures.

Study & Design

• Study Type: Interventional
• Study Design: Not specified