Effect of dexmedetomidine on central nervous system complications in patients undergoing cardiac surgery
Phase 1
Completed
- Conditions
- Postoperative complications of the central nervous system
- Registration Number
- ChiCTR2400081864
- Lead Sponsor
- The First Medical Center, Chinese PLA General Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Age range from 18 to 85 years old, regardless of gender<br>2. Patients who undergo cardiac surgery on a scheduled basis;<br>3. ASA level 1-4;<br>4. Obtain written informed consent form;
Exclusion Criteria
- Patients with MMSE scores less than 18 or dementia, intellectual disability, and inability to communicate (coma, severe dementia, hearing or language impairment);<br>2. Have a history of mental or neurological disorders (such as schizophrenia, epilepsy, Parkinson's disease, or severe myasthenia gravis);<br>3. Previous history of brain injury;<br>4. Severe liver dysfunction (Child pugh C-grade) or renal insufficiency (preoperative dialysis);<br>5. Severe bradycardia (heart rate below 50 beats per minute), pathological sinus syndrome, or atrioventricular block without a pacemaker;<br>6. Postoperative intensive care unit (ICU) duration exceeding 7 days or death;
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The incidence of postoperative depression;The incidence of postoperative anxiety;
- Secondary Outcome Measures
Name Time Method The incidence of postoperative delirium;Postoperative Pain;Postoperative sleep disorders;Postoperative quality of life evaluation;Postoperative mortality rate;Surgical related complications;