C-reactive protein assisted prescribing for respiratory tract infections to stimulate Antibiotic stewardship; a randomised controlled trial in general practice

Completed

Conditions: respiratory tract infections
10024970

Registration Number: NL-OMON31304

Lead Sponsor: Orion Diagnostica Oy

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 200

Inclusion Criteria

LRTI:
First consultation of current episode of acute cough (duration <4 weeks)
Regarded by the GP to be caused by an acute lower respiratory tract infection
- At least one out of following 4:
Shortness of breath / wheezing / chest pain / auscultation abnormalities
- At least one of the following 5:
Fever / perspiring / headache / myalgia / feeling generally unwell
Rhinosinusitis:
First consultation of current episode of rhinosinusitis (duration <4 weeks)
At time of consultation both of the following signs / symptoms:
1. purulent nasal discharge by self-report or by physical examination
2. unilateral or bilateral frontal or maxillary pain

Exclusion Criteria

Patients who require immediate admission to hospital
Patients who have no understanding of written and/or Dutch language
Patients who previously participated in the study
Patients who currently use antibiotic or have taken an antibiotic in the past 2 weeks
Patients who have been hospitalized in the past 2 weeks
Severely immuno-compromised patients

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Prescribing rates at index consultation (day 0), defined as immediate, delayed<br /><br>or no antibiotics </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Total antibiotic exposure over a period of 28 days, defined as the number of<br /><br>patients receiving immediate antibiotics or filling a delayed prescription for<br /><br>antibiotics within 28 days of index consultation (day 0)<br /><br>- Clinical recovery<br /><br>- Patient satisfaction and enablement<br /><br>- Reconsultation within 28 days<br /><br>- Evaluation of GPs' estimation of CRP value based on usual diagnostic work-up<br /><br>(medical history and physical examination) compared to actual CRP test result.<br /><br>- CRP value on day 0 and day 7 in relation to perceived degree of illness (VAS,<br /><br>Visual Analogue Scale). </p><br>